A randomized study of carbamazepine versus no medication after a first unprovoked seizure in childhood.

@article{Camfield1989ARS,
  title={A randomized study of carbamazepine versus no medication after a first unprovoked seizure in childhood.},
  author={Peter R Camfield and Carol S Camfield and Joseph M. Dooley and Edward Clinton Smith and Brett Garner},
  journal={Neurology},
  year={1989},
  volume={39 6},
  pages={851-2}
}
We randomized 31 children with a 1st afebrile unprovoked seizure to receive carbamazepine (CBZ) or no medication for 1 year or until the time of a 2nd seizure. All seizures had a focal onset or were generalized tonic-clonic. Overall, 2/14 randomized to CBZ and 9/17 with no medication had a recurrent afebrile seizure. Compliance with CBZ was excellent in 12/14, but noncompliance may have contributed to 1 of the recurrences with CBZ. Four discontinued CBZ because of side effects. Two additional… CONTINUE READING

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