A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study).

@article{Orkin2005ARS,
  title={A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study).},
  author={Chloe M. Orkin and Justin Stebbing and David D. Nelson and Mark Bower and Margaret Fullerton Johnson and Sundhiya Mandalia and Rachael G. Jones and Graeme Moyle and Martin Fisher and Brian Gazzard},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 2},
  pages={
          246-51
        }
}
BACKGROUND Evidence from randomized controlled trials supports the use of triple therapy. Research is required on the effectiveness of quadruple therapy in comparison to this and the relative effectiveness of specific highly active antiretroviral therapy (HAART) combinations. METHODS Antiretroviral-naive individuals (n = 53) with an HIV-1 viral load >100 000 copies/mL were randomized to receive three-drug HAART with zidovudine/lamivudine (Combivir) and efavirenz or quadruple therapy with… CONTINUE READING

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