A randomized prospective study of oral versus intravenous antibiotic prophylaxis against postoperative infection after sagittal split ramus osteotomy of the mandible.

@article{Yoda2000ARP,
  title={A randomized prospective study of oral versus intravenous antibiotic prophylaxis against postoperative infection after sagittal split ramus osteotomy of the mandible.},
  author={Tetsuya Yoda and Eduardo Sakai and Kazutoki Harada and Masatomo Mori and Ichiro Sakamoto and Shoji Enomoto},
  journal={Chemotherapy},
  year={2000},
  volume={46 6},
  pages={438-44}
}
BACKGROUND We investigated whether oral levofloxacin was as effective as intravenous cefazolin sodium for preventing postoperative infections in patients undergoing sagittal split ramus osteotomy of the mandible. METHODS Forty-four patients were randomized to treatment with levofloxacin or cefazolin sodium. Levofloxacin (100 mg t.d.s.) was administered orally, and cefazolin sodium (1 g b.i.d.) by intravenous infusion. Both drugs were given until 5 days postoperatively. The concentrations of… CONTINUE READING

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