A randomized prospective clinical trial to determine the efficacy of interferon-gamma in severely injured patients.

@article{Polk1992ARP,
  title={A randomized prospective clinical trial to determine the efficacy of interferon-gamma in severely injured patients.},
  author={Hiram C. Polk and William G. Cheadle and David H. Livingston and Jorge Iv{\'a}n Lizarazo Rodr{\'i}guez and Karen M. Starko and Allen E. Izu and Howard S. Jaffe and Gerald Sonnenfeld},
  journal={American journal of surgery},
  year={1992},
  volume={163 2},
  pages={191-6}
}
Many aspects of the normal immune response are depressed after severe injury. Reduced monocyte human leukocyte antigen-DR (HLA-DR) levels have closely correlated with the development of major infection. After a pilot study with recombinant interferon-gamma (rIFN-gamma) showed restoration of depressed HLA-DR levels after major injury, a multicenter, prospective, randomized, double-blind trial was conducted. Two hundred thirteen trauma patients who were at high risk of infection received either… CONTINUE READING
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