A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial.

@article{Lipworth2012ARP,
  title={A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial.},
  author={Brian J Lipworth and Philip M. Short and Peter Andrew Williamson and Karine L. Clearie and Thomas C. Fardon and Cathy M. Jackson},
  journal={Chest},
  year={2012},
  volume={141 3},
  pages={
          607-615
        }
}
BACKGROUND We compared titrating inhaled corticosteroid (ICS) against mannitol airway hyperresponsiveness (AHR) or a reference strategy (control) based on symptoms, reliever use, and lung function in primary care. METHODS One hundred sixty-four patients with persistent asthma were randomized in parallel group fashion following an initial ICS tapering. Subsequent ICS doses (as ciclesonide) were titrated against either the provocative dose of mannitol causing a 10% fall in FEV(1) (PD(10)) (AHR… CONTINUE READING
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