A randomized placebo-controlled trial of metformin for the treatment of HIV lipodystrophy.

OBJECTIVE We conducted a randomized placebo-controlled trial to examine the effects of metformin on visceral adipose tissue (VAT), appendicular fat, lipid profile and insulin sensitivity in HIV-infected persons with central adiposity and mild insulin resistance. METHODS Forty-eight HIV-infected men and women with a self-reported increase in abdominal… CONTINUE READING