A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study.

@article{Weick1996ARI,
  title={A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study.},
  author={James K. Weick and Kenneth J. Kopecky and F R Appelbaum and David R. Head and Linda Kingsbury and Stanley P. Balcerzak and John N. Bickers and Harry E. Hynes and Jeanna Welborn and Sanford R. Simon and Michael R Grever},
  journal={Blood},
  year={1996},
  volume={88 8},
  pages={2841-51}
}
Interest in high-dose cytarabine (HDAC) for both induction and postremission therapy for acute myeloid leukemia (AML) prompted the Southwest Oncology Group (SWOG) to initiate a randomized trial comparing HDAC with standard-dose cytarabine (SDAC) for remission induction of previously untreated AML and to compare high-dose treatment versus conventional doses for consolidation therapy. Patients less than 65 years of age with de novo or secondary AML were randomized for induction between SDAC 200… CONTINUE READING

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