A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study.

@article{Cook2007ARF,
  title={A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study.},
  author={Nancy R. Cook and Christine M. Albert and J. Michael Gaziano and Elaine Zaharris and Jean G Macfadyen and Eleanor Danielson and Julie E. Buring and Joann E. Manson},
  journal={Archives of internal medicine},
  year={2007},
  volume={167 15},
  pages={1610-8}
}
BACKGROUND Randomized trials have largely failed to support an effect of antioxidant vitamins on the risk of cardiovascular disease (CVD). Few trials have examined interactions among antioxidants, and, to our knowledge, no previous trial has examined the individual effect of ascorbic acid (vitamin C) on CVD. METHODS The Women's Antioxidant Cardiovascular Study tested the effects of ascorbic acid (500 mg/d), vitamin E (600 IU every other day), and beta carotene (50 mg every other day) on the… CONTINUE READING
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