A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.

@article{Harrigan2004ARE,
  title={A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.},
  author={Edmund P. Harrigan and Jeffrey J Miceli and Richard J. Anziano and Eric Jacob Watsky and Karen R. Reeves and Neal R. Cutler and Juraj {\vS}r{\'a}mek and Thomas M. Shiovitz and Michelle Middle},
  journal={Journal of clinical psychopharmacology},
  year={2004},
  volume={24 1},
  pages={
          62-9
        }
}
Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The effects of 6 antipsychotics on the QTc interval at and around the time of estimated peak plasma/serum concentrations in the absence and presence of metabolic inhibition were characterized in a prospective, randomized study in which patients with psychotic disorders reached steady-state on either haloperidol 15 mg/d (n = 27), thioridazine 300 mg… CONTINUE READING

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