A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group.

@article{Dube1997ARE,
  title={A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group.},
  author={Michael Dube and Fred R. Sattler and Francesca J. Torriani and Donna See and Diane V. Havlir and Carol A. Kemper and M G Dezfuli and Samuel A. Bozzette and Andrea Bartok and John M. Leedom and Jeremiah G. Tilles and John McCutchan},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={176 5},
  pages={
          1225-32
        }
}
Patients with AIDS and Mycobacterium avium complex (MAC) bacteremia are at high risk for relapse and emergence of resistant isolates during monotherapy with clarithromycin. Ninety-five AIDS patients with MAC bacteremia received clarithromycin plus clofazimine, with or without ethambutol, in a prospective, multicenter, randomized open-label trial. Of 80 patients with positive baseline cultures, sterilization or a 2 log10 reduction in colony-forming units of MAC in two consecutive blood cultures… CONTINUE READING

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