A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.

Abstract

BACKGROUND Antiepileptic drugs are commonly used to prevent seizures that may follow head trauma. However, previous controlled studies of this practice have been inconclusive. METHODS To study further the effectiveness of phenytoin (Dilantin) in preventing post-traumatic seizures, we randomly assigned 404 eligible patients with serious head trauma to… (More)

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@article{Temkin1990ARD, title={A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.}, author={Nancy R. Temkin and Sureyya S. Dikmen and Alan J. Wilensky and J Keihm and Sarah Chabal and H. Richard Winn}, journal={The New England journal of medicine}, year={1990}, volume={323 8}, pages={497-502} }