A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood.

@article{Serfaty2010ARD,
  title={A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood.},
  author={Marc Serfaty and Debbie Osborne and Marta Buszewicz and Robert Blizard and Peter W. Raven},
  journal={International clinical psychopharmacology},
  year={2010},
  volume={25 3},
  pages={
          132-42
        }
}
Sleep disturbance is common in major depressive disorder (MDD), and is often characterized by early-morning waking. Melatonin is a hypnotic and synchronizes circadian rhythms. It may also be an antidepressant. The melatonin agonists, ramelteon and agomelatine, have hypnotic and antidepressant properties, but there is a dearth of trials investigating the use of melatonin in MDD. This randomized, controlled trial aimed to determine whether exogenous melatonin is a sleep promoter and… CONTINUE READING

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