A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder

  title={A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder},
  author={H M Standish-Barry and Nick Bouras and Paul K. Bridges and James P. Watson},
A randomized double blind group comparison study of sulpiride and amitriptyline was carried out in 36 patients suffering from major depressive disorder (DSM III critieria). Sulpiride showed equivalent antidepressant activity to amitriptyline at 4, 6 and 12 weeks, using the Hamilton Rating Scale (HRS) and the Wakefield Self-Rating Scale for depression (WRS). However, at 24 weeks the antidepressant activity of amitriptyline was just statistically significantly better than that of sulpiride… 

Combined Treatment With Sulpiride and Paroxetine for Accelerated Response in Patients With Major Depressive Disorder

The efficacy of adjunctive sulpiride in combination with paroxetine (PAX) compared with PAX alone was examined to clarify whether the combined treatment exerts faster effect, and the combination treatment may be a safe and effective strategy for accelerating antidepressant response.

Effects of sulpiride and chlorpromazine on depressive symptoms in schizophrenic patients — relationship to drug concentrations

It was found that patients with low concentrations of sulpiride or CPZ in serum recovered more completely from depressive symptoms and had fewer extrapyramidal side effects than patients with high drug concentrations.

The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function

After 16 weeks of cognitive behavioural therapy (CBT), an enhanced prolactin response to sulpiride was detected, suggesting an increased sensitivity of D2 receptor functioning.

Uso de sulpirida versus placebo na redução de fogachos durante o climatério : ensaio clínico randomizado

The results suggest that the Sulpiride 50mg/day treatment showed significant trends on reducing climacteric vasomotor symptoms, justifying replication and further studies addressing the possible mechanisms by which SulPiride could safely reduce hot flushes.

Neurophysiological and Psychophysiological Effects of Sulpiride in the Norm and in Patients with Opiate Addiction

Dynamics of the indices of psychophysiological testing after sulpiride treatment demonstrated that the drug exerts mostly positive regulating effects on the state of higher nervous functions in patients with opiate addiction.

Antipsychotics possessing antidepressive efficacy increase Golf protein in rat striatum

It is postulated that the increase in Golf protein levels result in an increase the proportion of D1 receptors in the high-affinity state and that augmentation of the dopaminergic system exerts the antidepressant effect.

Die dopaminerge Verankerung der Extraversion: Mechanismen und EEG-Indikatoren

The present study aimed to specify the mechanisms underlying opposite effects of dopamine D2 receptor antagonist Sulpiride using the following recently reported scenario as an example and supported a model postulating stronger preversus postsynaptic receptor effects in high aE Individuals compared to low aE individuals.

Risks of Sulpiride-Induced Parkinsonism in Peptic Ulcer and Gastroesophageal Reflux Disease Patients in Taiwan: A Nationwide Population-Based Study

At the population level, sulpiride may be frequently prescribed and apparently effective for PUD and GERD patients, but SIP is associated with older age, hypertension, depression or anxiety comorbidities.

The nucleus accumbens and antidepressants: modulation of ergometrine-induced hyperactivity by typical and atypical antidepressants and neuroleptics in rats

  • A. Cools
  • Psychology, Biology
  • 2004
The hypothesis that drugs with antidepressive effects mediate their behavioural effects via mesolimbic (-)sulpiride binding sites is discussed in terms of the hypothesis that books with high affinity and low affinity bind neuroleptics with low affinity.



A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.

Flupenthixol, in low dosage, is a useful alternative antidepressant for depressed outpatients and lessened anxiety scores more than amitriptyline, but the trends favoured flupenthIXol.

A Controlled Comparison of Flupenthixol Decanoate Injections and Oral Amitriptyline in Depressed Out-Patients

Flupenthixol decanoate in low dose is a useful anti-depressant, but should be restricted to short courses of treatment, to patients refractory to other treatments, and to patients suspected of poor compliance.

Controlled Trial of Sulpiride in Chronic Schizophrenic Patients

The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine.

Effect of sulpiride on monoaminergic mechanisms in psychotic women

The biochemical data indicate that clinical doses of sulpiride blocked dopamine receptors in the nigrostriatal pathway as well as in the tuberoinfundibular system and was associated with marked reductions in psychotic morbidity.

Chlorimipramine in the Treatment of Severe Depression

  • M. Abenson
  • Medicine, Psychology
    British Journal of Psychiatry
  • 1971
Flupenthixol is regarded as a most interesting and potentially useful antidepressant and it is predicted that controlled trials, when undertaken, will show it to be an active drug.

Sulpiride: evaluation of antipsychotic activity in schizophrenic patients.

The overall findings support those studies reporting neuroleptic activity of Sulpiride, and toxic levels appear to be well beyond the therapeutic range.

Flupenthixol (Fluanxol)

  • H. Merskey
  • Medicine, Psychology
    British Journal of Psychiatry
  • 1971
Flupenthixol is regarded as a most interesting and potentially useful antidepressant and it is predicted that controlled trials, when undertaken, will show it to be an active drug.

Effect of sulpiride on serum prolactin levels in humans.

It is suggested that sulpiride could be used in the dynamic functional exploration of hypothalamic-pitutiary system by inducing a quick and marked increment of serum prolactin levels with peak values at 30 minutes.

Benzamides and classical neuroleptics: comparison of their actions using 6 apomorphine-induced effects.

An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels.

It appears that central dopaminergic blockade in the hypothalamic area is not a prerequisite for antipsychotic activity and sulpiride has a low potential for producing tardive dyskinesia.