A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder

@article{StandishBarry2004ARD,
  title={A randomized double blind group comparative study of sulpiride and amitriptyline in affective disorder},
  author={H M Standish-Barry and Nick Bouras and Paul K. Bridges and James P. Watson},
  journal={Psychopharmacology},
  year={2004},
  volume={81},
  pages={258-260}
}
A randomized double blind group comparison study of sulpiride and amitriptyline was carried out in 36 patients suffering from major depressive disorder (DSM III critieria). Sulpiride showed equivalent antidepressant activity to amitriptyline at 4, 6 and 12 weeks, using the Hamilton Rating Scale (HRS) and the Wakefield Self-Rating Scale for depression (WRS). However, at 24 weeks the antidepressant activity of amitriptyline was just statistically significantly better than that of sulpiride… 

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