A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways.

@article{Tans2000ARC,
  title={A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways.},
  author={Guido Tans and Joyce Curvers and Saskia Middeldorp and M Christella L G D Thomassen and Joost C M Meijers and Martin H. Prins and Bonno N. Bouma and Harry Roger B{\"u}ller and Jan Rosing},
  journal={Thrombosis and haemostasis},
  year={2000},
  volume={84 1},
  pages={15-21}
}
The use of oral contraceptives (OC) causes disturbances of the procoagulant, anticoagulant and fibrinolytic pathways of blood coagulation which may contribute to the increased risk of venous thrombosis associated with OC therapy. Here we report the results of a cycle-controlled randomized cross-over study, in which we determined the effects of so-called second and third generation OC's on a number of anticoagulant parameters. In this study, 28 non-OC using women were randomly prescribed either… CONTINUE READING

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