A randomized cross-over study of the efficacy of codeine phosphate versus Ispaghulahusk in patients with gynaecological cancer experiencing diarrhoea during pelvic radiotherapy.

  title={A randomized cross-over study of the efficacy of codeine phosphate versus Ispaghulahusk in patients with gynaecological cancer experiencing diarrhoea during pelvic radiotherapy.},
  author={N Lodge and Manon Evans and M Wilkins and Peter R. Blake and I. J. Fryatt},
  journal={European journal of cancer care},
  volume={4 1},
Diarrhoea is the commonest acute complication during radiotherapy treatment to the pelvis. Codeine phosphate and a low residue diet is the standard therapy for radiation-induced diarrhoea at The Royal Marsden NHS Trust. The hypothesis put forward was that Ispaghulahusk and codeine phosphate were equally effective in the treatment of diarrhoea during radiotherapy. Participants in the study were female patients who had experienced change of bowel habit whilst receiving radiotherapy for their… 
Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy.
To assess the effects of nutritional interventions for reducing GI toxicity in adults undergoing radical pelvic radiotherapy, the Cochrane Gynaecological Cancer Group's Trials Register and Cochrane Central Register of Controlled Trials was searched.
The Efficacy of Dietary Fiber in Managing Gastrointestinal Toxicity Symptoms in Patients with Gynecologic Cancers undergoing Pelvic Radiotherapy: A Systematic Review.
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Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy.
Dietary advice to follow a high-fiber diet during pelvic radiotherapy resulted in reduced gastrointestinal toxicity both acutely and at 1 y compared with habitual-Fiber intake, and Restrictive, non-evidence-based advice to reduce fiber intake in this setting should be abandoned.
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A Study on the Effect of Dietary Modifications in decreasing or delaying Radiation Induced Acute Gastrointestinal Adverse Events in patients receiving Pelvic Radiotherapy
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Nutritional strategies to prevent gastrointestinal toxicity during pelvic radiotherapy
  • L. Wedlake
  • Medicine
    Proceedings of the Nutrition Society
  • 2018
It is concluded that there is insufficient high-grade evidence to recommend nutritional intervention during pelvic radiotherapy and probiotics offer promise but cannot be introduced into clinical practice without rigorous safety analysis, not least in immunocompromised patients.
Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis.
This review found that in spite of the two studies of level IIA evidence, the absence of randomised controlled trials makes it impossible to draw any firm conclusions about the management of late chronic radiation cystitis.
Effects of a dietary intervention on acute gastrointestinal side effects and other aspects of health-related quality of life: a randomized controlled trial in prostate cancer patients undergoing radiotherapy.
The tendency towards lower prevalence of bowel symptoms in IG may indicate some positive effect of the dietary intervention, but methodological refinements, clearer results and longer follow-up are needed before the value of diet change can be established with certainty.
Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: long-term results from a randomized controlled trial.
Dietary intervention had no obvious effect on long-term gastrointestinal symptoms or HRQOL, and dietary intervention was not superior to a usual diet in preventing these symptoms.
Evaluated studies show controversial or inconclusive results regarding the influence of nutrients in the radiotherapy and it has been not found Sorong evidence about their role in patients receiving ionizing radiation.