A randomized controlled trial to evaluate the slow-acting symptom modifying effects of a regimen containing colchicine in a subset of patients with osteoarthritis of the knee.

@article{Das2002ARC,
  title={A randomized controlled trial to evaluate the slow-acting symptom modifying effects of a regimen containing colchicine in a subset of patients with osteoarthritis of the knee.},
  author={Siddharth K Das and Kavita Mishra and Subramaniam Ramakrishnan and Ragini Srivastava and Girdhar G. Agarwal and Ragini Singh and Amulya R Sircar},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 4},
  pages={247-52}
}
OBJECTIVE As crystals may contribute to inflammation in osteoarthritis (OA), it is hypothesized that colchicine may have symptom/disease modifying effects in OA. The objective of this study was to evaluate the symptomatic benefit of addition of colchicine to a regimen of intraarticular steroids and piroxicam in patients with knee OA with inflammation. DESIGN 39 patients with OA of the knee with persisting inflammation, despite at least 2 weeks of piroxicam, were subjected to intraarticular… CONTINUE READING
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