A randomized controlled trial of low-dose aspirin in women at risk from pre-eclampsia.

Abstract

OBJECTIVES To determine whether low-dose aspirin reduces the incidence of pre-eclampsia, reduces perinatal mortality and improves birth weights in pregnant women considered at high risk of developing pre-eclampsia. METHOD Two-hundred fifty subjects were recruited from the antenatal clinics at Harare Central Hospital with either a previous history of pregnancy-induced hypertension or pre-existing chronic hypertension and were randomized to receive either 75 mg of aspirin (ASA) or placebo (PLA). RESULTS Two-hundred thirty subjects (ASA, n = 113; PLA, n = 117) completed the trial. The odds of developing pre-eclampsia for those on aspirin was 0.72 times those on placebo (95% CI, 0.34-1.52). The mean birth weight was 2774 g for those on aspirin and 2694 g for those on placebo (P = 0.80). No difference was noted in the perinatal deaths (OR = 0.38; 95% CI, 0.10-1.20). CONCLUSION Prophylactic use of aspirin was not associated with a significant effect on the major pregnancy outcomes assessed in this study.

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@article{Byaruhanga1998ARC, title={A randomized controlled trial of low-dose aspirin in women at risk from pre-eclampsia.}, author={Romano N. Byaruhanga and Tsungai Chipato and Simbarashe Rusakaniko}, journal={International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics}, year={1998}, volume={60 2}, pages={129-35} }