A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.

@article{Goldberg2004ARC,
  title={A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer.},
  author={Richard M. Goldberg and Daniel J. Sargent and Roscoe F. Morton and Charles S. Fuchs and Ramesh K. Ramanathan and Stephen Castles Magdalena Arias Cubas Chulhyo Kim Elsa Kol Williamson and Brian P Findlay and Henry C. Pitot and Steven Robert Alberts},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 1},
  pages={23-30}
}
PURPOSE Three agents with differing mechanisms of action are available for treatment of advanced colorectal cancer: fluorouracil, irinotecan, and oxaliplatin. In this study, we compared the activity and toxicity of three different two-drug combinations in patients with metastatic colorectal cancer who had not been treated previously for advanced disease. PATIENTS AND METHODS Patients were concurrently randomly assigned to receive irinotecan and bolus fluorouracil plus leucovorin (IFL, control… CONTINUE READING
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