A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.

  title={A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.},
  author={Khanh Duy Vu and Naifa Lamki Busaidy and Maria E Cabanillas and Marina Y Konopleva and Stefan H Faderl and Deborah A. Thomas and Susan O'brien and Kristine R. Broglio and Joe D Ensor and Carmen Escalante and Michael Andreeff and Hagop A Kantarjian and Victor R Lavis and Sai-Ching Jim Yeung},
  journal={Clinical lymphoma, myeloma & leukemia},
  volume={12 5},
UNLABELLED Hyperglycemia during hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine, with methylprednisolone premedication) chemotherapy is associated with poor outcomes of acute lymphoblastic leukemia (ALL). To examine whether intensive insulin therapy could improve outcomes, a randomized trial was conducted that compared glargine plus aspart vs. conventional therapy. Intensive insulin did not improve ALL… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

Impact of chemotherapy-related hyperglycemia on prognosis of child acute lymphocytic leukemia.

Asian Pacific journal of cancer prevention : APJCP • 2014
View 3 Excerpts
Highly Influenced

Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.

The journals of gerontology. Series A, Biological sciences and medical sciences • 2016
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 30 references

The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth

RJ Dowling, M Zakikhani, IG Fantus
J Cell Mol Med • 2011

Prognostic significance of CD 20 expression in adults with de novo precursor Blineage acute lymphoblastic leukemia

X Chen, TO Scholl
Blood • 2009

via PPARgammadependent and PPARgammaindependent pathways

YW Dong, XP Wang, K Wu
Cell Cycle • 2009

Effect of tight control of blood glucose during hyperCVAD chemotherapy for acute lymphocytic leukemia

DA Thomas, S O’Brien, JL Jorgensen
Blood • 2008

Similar Papers

Loading similar papers…