A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating

@article{Kim2005ARC,
  title={A randomized controlled trial of a probiotic combination VSL\# 3 and placebo in irritable bowel syndrome with bloating},
  author={H. Jae Kim and Maria I Vazquez Roque and Michael Joseph Camilleri and Debra A Stephens and Duane Burton and Kari L Baxter and George M. Thomforde and A. R. Zinsmeister},
  journal={Neurogastroenterology \& Motility},
  year={2005},
  volume={17}
}
Abstract  Aim:  To evaluate the effects of a combination probiotic on symptoms and colonic transit in patients with irritable bowel syndrome (IBS) and significant bloating. 

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References

SHOWING 1-10 OF 55 REFERENCES

A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome

Aim : To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of patients with Rome II irritable bowel syndrome with predominant diarrhoea.

Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5‐HT3 receptor antagonist

TLDR
Colonic sensory and motor function are modulated partly through 5HT3‐receptors, and no currently available treatment provides consistent relief of irritable bowel syndrome.

Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea

TLDR
This data indicates that using probiotic preparations based on isolating Lactobacillus spp.

Probiotics in The Treatment of Irritable Bowel Syndrome

  • A. Saggioro
  • Medicine
    Journal of clinical gastroenterology
  • 2004
TLDR
In conclusion, short-term therapy with Lactobacillus PlantarumLP0 1 and Bifidocterium Breve BR0 may be considered a promising approach to the therapy for IBS.

Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.

TLDR
B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.

Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome

TLDR
The results of the study indicate that the administration of Lb.

Lactobacillus plantarum 299: Beneficial in vitro immunomodulation in cells extracted from inflamed human colon

TLDR
The pattern of cytokine secretion and their cellular sources in mononuclear cells isolated from colonic mucosa from normal and ulcerative colitis in response to probiotic and pathogenic bacteria is determined.

Intestinal microflora and oral bacteriotherapy in irritable bowel syndrome.

...