A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating

  title={A randomized controlled trial of a probiotic combination VSL\# 3 and placebo in irritable bowel syndrome with bloating},
  author={H. Jae Kim and Maria I Vazquez Roque and Michael Joseph Camilleri and Debra A Stephens and Duane Burton and Kari L Baxter and George M. Thomforde and A. R. Zinsmeister},
  journal={Neurogastroenterology \& Motility},
Abstract  Aim:  To evaluate the effects of a combination probiotic on symptoms and colonic transit in patients with irritable bowel syndrome (IBS) and significant bloating. 

Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double‐blind placebo‐controlled study

This data indicates that using probiotics to treat irritable bowel syndrome with a low dose increases the likelihood that the drug will be effective in the long term.

Systematic review and meta‐analysis: Efficacy of patented probiotic, VSL#3, in irritable bowel syndrome

VSL#3 is a patented probiotic for which several clinical trials suggest benefits on motor function, bloating, and symptoms of irritable bowel syndrome (IBS).

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus

In 2013, a systematic review and Delphi consensus reported that specific probiotics can benefit adult patients with irritable bowel syndrome (IBS) and other gastrointestinal (GI) problems.

Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota

A small number of patients diagnosed with irritable bowel syndrome with a history of diarrhoea or constipation are treated with probiotics, a type of probiotic, which can be beneficial in the absence of bowel problems.

Systematic review with meta‐analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome

It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for IBS preoperatively on the basis of prior history and once they provide informed consent for surgery.

Review article: probiotics for the treatment of irritable bowel syndrome – focus on lactic acid bacteria

The withdrawal, due to adverse events, of a number of pharmacological agents that were approved for the treatment of IBS has left a therapeutic vacuum for patients suffering from the disorder.

Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence-based international guide

Evidence suggests that the gut microbiota play an important role in gastrointestinal problems and the importance of knowing the phytochemical components of the gut flora is important for the protection of against disease.

Is there a role for probiotics in irritable bowel syndrome?

  • M. Camilleri
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2006

Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta‐analysis

A systematic review and meta‐analysis were performed to investigate the quantity and quality of the current evidence regarding the effect of different probiotic strains in the treatment of functional



A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome

Aim : To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of patients with Rome II irritable bowel syndrome with predominant diarrhoea.

Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5‐HT3 receptor antagonist

Colonic sensory and motor function are modulated partly through 5HT3‐receptors, and no currently available treatment provides consistent relief of irritable bowel syndrome.

Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea

This data indicates that using probiotic preparations based on isolating Lactobacillus spp.

Probiotics in The Treatment of Irritable Bowel Syndrome

  • A. Saggioro
  • Medicine
    Journal of clinical gastroenterology
  • 2004
In conclusion, short-term therapy with Lactobacillus PlantarumLP0 1 and Bifidocterium Breve BR0 may be considered a promising approach to the therapy for IBS.

Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.

B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.

Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome

The results of the study indicate that the administration of Lb.

Lactobacillus plantarum 299: Beneficial in vitro immunomodulation in cells extracted from inflamed human colon

The pattern of cytokine secretion and their cellular sources in mononuclear cells isolated from colonic mucosa from normal and ulcerative colitis in response to probiotic and pathogenic bacteria is determined.

Intestinal microflora and oral bacteriotherapy in irritable bowel syndrome.