A randomized clinical trial of intrathecal magnesium sulfate versus midazolam with epidural administration of 0.75% ropivacaine for patients with preeclampsia scheduled for elective cesarean section

  title={A randomized clinical trial of intrathecal magnesium sulfate versus midazolam with epidural administration of 0.75\% ropivacaine for patients with preeclampsia scheduled for elective cesarean section},
  author={Sophia Paleti and P. K. Prasad and B. S. Lakshmi},
  journal={Journal of Anaesthesiology, Clinical Pharmacology},
  pages={23 - 28}
Background and Aims: Magnesium sulfate and midazolam have been used as adjuvants to local anesthetics via intrathecal and epidural routes to augment the quality of block and prolong postoperative analgesia. This study compares addition of intrathecal magnesium sulfate versus intrathecal midazolam to epidurally administered isobaric ropivacaine as a part of combined spinal epidural technique in pre-eclamptic parturients undergoing elective cesarean section. Material and Methods: After… Expand
Efficacy and safety of intrathecal meropenem and vancomycin in the treatment of postoperative intracranial infection in patients with severe traumatic brain injury
Intrathecal meropenem and vancomycin is more effective than intravenous administration in the treatment of intracranial infection after craniotomy and can significantly shorten the treatment time and reduce the treatment cost, with better safety. Expand
El uso de sulfato de magnesio como adyuvante en el bloqueo regional neuroaxial. Metaanálisis
  • Marco Antonio  García Mora, Cristhofer Abel  Torres González,  Francisco Javier  Hernández Hernández, Constanza Iara Rusz Ahuad
  • Medicine
  • 2020


A Randomized Study of Magnesium Sulfate as an Adjuvant to Intrathecal Bupivacaine in Patients With Mild Preeclampsia Undergoing Cesarean Section
It is confirmed that magnesium sulfate, which has previously been found to be a safe and effective spinal adjuvant in normal parturients, is also safe andeffective for women with mild preeclampsia undergoing cesarean section. Expand
Clinical effects of intrathecal midazolam versus intrathecal magnesium sulfate as adjunctsto hyperbaric bupivacaine: A comparative study
50 mg of intrathecal magnesium sulfate prolonged the duration of sensory and motor block and also theduration of postoperative analgesia with low pain scores as compared to midazolam group, however, it delayed the onset of sensoryand motor block. Expand
Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: a randomized, double-blind trial in patients undergoing lower extremity surgery
In patients undergoing lower extremity surgery with spinal anesthesia, the addition of 100 mg IT MgSO4 to 15 mg bupivacaine without opioid supplement prolonged the duration of the sensory block, decreased postoperative analgesic consumption, and significantly prolonged the onset of spinal anesthesia. Expand
A comparison of intrathecal dexmedetomidine verses intrathecal fentanyl with epidural bupivacaine for combined spinal epidural labor analgesia
Comparison of the duration and quality of analgesia, maternal and neonatal outcomes after CSE labor analgesia with intrathecal dexmedetomidine and intrathecally fentanyl followed by epidural bupivacaine shows 10 μg dexmedETomidine intrathe cally provides a longer duration of analgesIA with lesser incidence of pruritus. Expand
The effect of adding magnesium sulphate to epidural bupivacaine and fentanyl in elective caesarean section using combined spinal-epidural anaesthesia: a prospective double blind randomised study.
The addition of magnesium to epidural bupivacaine and fentanyl in women undergoing elective caesarean section with combined spinal-epidural anaesthesia improved intraoperative conditions and the quality of postoperative analgesia. Expand
Intrathecal Magnesium Prolongs Fentanyl Analgesia: A Prospective, Randomized, Controlled Trial
Intrathecal magnesium prolongs spinal opioid analgesia in humans and suggest that the availability of an intrathecal N-methyl-d-aspartate receptor antagonist could be of clinical importance for pain management. Expand
Use of Intrathecal Midazolam to Improve Perioperative Analgesia: A Meta-Analysis
Based on the limited data available, intrathecal midazolam appears to improve perioperative analgesia and reduce nausea and vomiting during caesarean delivery and a multicentre registry or large randomised controlled study with a prolonged follow-up period would be useful to confirm the clinical safety of intr atherosclerosis. Expand
Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids: a systematic review and meta-analysis.
The duration of spinal anaesthesia may be increased by the addition of magnesium to lipophilic opioids ± LA in patients undergoing all types of surgery and in women in labour. Expand
Combined intrathecal and epidural magnesium sulfate supplementation of spinal anesthesia to reduce post‐operative analgesic requirements: a prospective, randomized, double‐blind, controlled trial in patients undergoing major orthopedic surgery
This work investigated whether supplementation of spinal anesthesia with combined intrathecally and epidurally infused MgSO4 reduced patients’ post‐operative analgesia requirements. Expand
Comparison of intrathecal magnesium, fentanyl, or placebo combined with bupivacaine 0.5% for parturients undergoing elective cesarean delivery
This prospective, randomized, double‐blind, study investigated the sensory, motor, and analgesic block characteristics of i.t. administration of magnesium to potentiate opioid antinociception in rats and humans. Expand