A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder.

@article{Sousa2006ARC,
  title={A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder.},
  author={Marcelo Basso de Sousa and Luciano Rassier Isolan and Renata R Oliveira and Gisele Gus Manfro and Aristides Volpato Cordioli},
  journal={The Journal of clinical psychiatry},
  year={2006},
  volume={67 7},
  pages={
          1133-9
        }
}
BACKGROUND Cognitive-behavioral group therapy (CBGT) and serotonin reuptake inhibitors have proven efficacy in reducing symptoms of obsessive-compulsive disorder (OCD). There is no consensus about which of these forms of treatment is more effective. This study was conducted to evaluate the efficacy of CBGT as compared to that of sertraline in reducing OCD symptoms. METHOD Fifty-six outpatients with an OCD diagnosis, according to DSM-IV criteria, participated in the randomized clinical trial… 
Cognitive-Behavioral Group Therapy versus Sertraline for Obsessive-Compulsive Disorder: Five-Year Follow-Up
TLDR
Whether the reduction in severity of OCD symptoms obtained with 12-weekly sessions of CBGT or with sertraline during the same period, in a randomized clinical trial, would be sustained over a 5-year period is investigated as well as to compare the differences between the 2 treatments in the long term.
Group cognitive-behavioral therapy versus selective serotonin reuptake inhibitors for obsessive-compulsive disorder: a practical clinical trial.
Clinical effectiveness of group cognitive-behavioral therapy (GCBT) versus fluoxetine in obsessive-compulsive disorder outpatients that could present additional psychiatric comorbidities was
Cognitive-coping therapy for obsessive-compulsive disorder: a randomized controlled trial.
TLDR
Pharmacotherapy plus CCT (PCCT) demonstrates higher efficacy in a shorter period of time and lower relapses than pharmacotherapy or pharmacotherapy plus CBT, and CCT might be a potential treatment for OCD.
A randomized controlled study of brief family-based intervention in obsessive compulsive disorder.
TLDR
Briefer intervention is effective in treating OCD and inclusive format of intervention has important implications for clinical practice in resource-constrained circumstances.
A promising randomized trial of a new therapy for obsessive–compulsive disorder
TLDR
The preliminary data suggest that PCCT is a more efficacious psychotherapy for OCD patients than pharmacotherapy or PCBT, and this approach in a larger sample size.
[Cognitive-behavior therapy for obsessive-compulsive disorder: a systematic review of the last decade].
TLDR
Cognitive and behavioral therapies have shown to be highly effective psychotherapeutic approaches for the treatment of obsessive-compulsive disorder, and exposure and response prevention associated with cognitive therapy may result in significant benefits to patients with predominant obsessive thoughts.
Behavioural group therapy for obsessive-compulsive disorder in Norway. An open community-based trial.
TLDR
The results indicate that behavioural group therapy can successfully be delivered to patients with considerable comorbidity in a real world setting conducted by therapists with limited training in the CBT.
Acceptance and Commitment Therapy, Selective Serotonin Reuptake Inhibitors and Their Combination in the Improvement of Obsessive-Compulsive Symptoms and Experiential Avoidance in Patients With Obsessive-Compulsive Disorder
TLDR
It appears that adding SSRIs to ACT does not increase the effectiveness of ACT in the treatment of adults with OCD in the short-term, and patients treated with ACT and combined treatment experienced a significantly greater improvement in obsessive-compulsive symptoms and experiential avoidance at post-treatment.
Patient Rating of Therapeutic Factors and Response to Cognitive-Behavioral Group Therapy in Patients with Obsessive-Compulsive Disorder
TLDR
There was a significant interaction between improvement in obsessive-compulsive symptoms and patient rating of altruism, universality, interpersonal learning input and output, family re-enactment, self-understanding, and existential factors over time.
A Randomized Clinical Trial to Examine Enhancing Cognitive-Behavioral Group Therapy for Obsessive-Compulsive Disorder with Motivational Interviewing and Thought Mapping
TLDR
A randomized behavioral trial examined 12 weeks of manual directed CBGT, with the addition of individual sessions of Motivational Interviewing and Thought Mapping before CBGT successfully reduced OCD symptoms and was more effective than using CBGT group alone.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 47 REFERENCES
A Randomized Controlled Trial of Japanese Patients with Obsessive-Compulsive Disorder – Effectiveness of Behavior Therapy and Fluvoxamine
TLDR
Behavior therapy improved the condition of OCD patients more than fluvoxamine, and patients with lower baseline total Y-BOCS, past history of a major depressive episode and absence of cleaning compulsion improved more with fluv oxamine.
Cognitive-Behavioral Group Therapy in Obsessive-Compulsive Disorder: A Randomized Clinical Trial
TLDR
The results suggest that CBGT is effective in reducing the intensity of OCD symptoms and of overvalued ideas, and that it improves the OCD patient’s quality of life in a short period of time.
Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial.
TLDR
Children and adolescents with OCD should begin treatment with the combination of CBT plus a selective serotonin reuptake inhibitor or CBT alone, suggesting that combined treatment is less susceptible to setting-specific variations.
High-dose sertraline strategy for nonresponders to acute treatment for obsessive-compulsive disorder: a multicenter double-blind trial.
TLDR
Greater symptom improvement was seen in the high-dose sertraline group compared to the 200-mg/day dose group during continuation treatment, and Administration of higher than labeled doses of selective serotonin reuptake inhibitors may be a treatment option for certain OCD patients who fail to respond to standard acute treatment.
Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder.
TLDR
Results of the Y-BOCS total score, the NIMH score, and the global severity and improvement scores demonstrated a statistically significant superiority of sertraline compared with placebo.
Efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder.
TLDR
During the study's last 28 weeks, sertraline demonstrated greater efficacy than placebo in preventing dropout due to relapse or insufficient clinical response and acute exacerbation of OCD symptoms.
A 1 year double‐blind placebo‐controlled fixed dose study of sertraline in the treatment of obsessive‐compulsive disorder
TLDR
Results support the safety, efficacy and tolerability of daily doses of 50–200 mg of sertraline in the long-term treatment of patients with OCD.
Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder.
TLDR
Results support the safety and efficacy of daily dosages of 50, 100, and 200 mg of sertraline in the short-term treatment of patients with OCD.
A Comparison of Behavioral Group Therapy and Individual Behavior Therapy in Treating Obsessive-Compulsive Disorder
TLDR
Both individual and group interventions proved to be equally effective at reducing distress caused by OCD symptoms, general depression, and anxiety by the end of treatment, although patients in the individual behavior therapy condition demonstrated faster reductions in OCD symptom severity.
A double-blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorder.
TLDR
Over 12 weeks, fluvoxamine CR treatment was associated with a statistically significant and clinically relevant reduction in OCD severity and was found to be safe and well tolerated.
...
1
2
3
4
5
...