A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.

  title={A randomized clinical trial of 5\% topical minoxidil versus 2\% topical minoxidil and placebo in the treatment of androgenetic alopecia in men.},
  author={Elise A Olsen and Frank E. Dunlap and T Funicella and Judith A. Koperski and James M. Swinehart and Eduardo H. Tschen and Ronald J. Trancik},
  journal={Journal of the American Academy of Dermatology},
  volume={47 3},
BACKGROUND Topical minoxidil solution 2% stimulates new hair growth and helps stop the loss of hair in individuals with androgenetic alopecia (AGA). Results can be variable, and historical experience suggests that higher concentrations of topical minoxidil may enhance efficacy. OBJECTIVE The purpose of this 48-week, double-blind, placebo-controlled, randomized, multicenter trial was to compare 5% topical minoxidil with 2% topical minoxidil and placebo in the treatment of men with AGA… 

Efficacy and safety of a new 10% topical minoxidil versus 5% topical minoxidil and placebo in the treatment of male androgenetic alopecia: a trichoscopic evaluation

Five percent of topical minxidil was moderately superior to 10% topical minoxidil and placebo in increasing hair regrowth opposite to the expected, the irritation was marked for 10%topical minoxIDil.

Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men

The findings confirmed the superiority of 5% topical minoxidil to 1% topical MINOXidil in treating Japanese men with androgenetic alopecia.

Comparison between topical cetirizine with minoxidil versus topical placebo with minoxidil in female androgenetic alopecia: a randomized, double-blind, placebo-controlled study.

Topical cetirizine increases hair shaft thickness and results in a higher clinical improvement from patients' perspective with a good safety profile (NCT04481412, study start date: July 2020).

Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study.

Cetirizine 1% solution was effective in hair growth without any complications for treatment of male AGA, and the improvement was much higher in the minoxidil group.

Comparative Study to Evaluate Tolerability of Topical 5% Minoxidil Novel Formulation and Alcohol-Based Conventional Solutions in Treatment of Androgenetic Alopecia in Indian Men: Randomized Double-Blind Study

Introduction Patients with androgenetic alopecia treated with alcohol-based minoxidil topical solutions often report local irritation, dryness, and redness of the scalp. We evaluate the in-use

An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

Both drugs were effective and safe in the treatment of mild to severe AGA, although oral finasteride treatment was more effective (p < 0.05); side effects were all mild, and there was no need to stop the treatment.

Comparing the Effectiveness of Local Solution of Minoxidil and Caffeine 2.5% with Local Solution of Minoxidil 2.5% in Treatment of Androgenetic Alopecia

This study overtly showed that the effect of caffeine + minoxidil topical solution 2.5% to treat AGA was better than minoxido topical solution 1.5%.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects and highly significant increase in hair density was achieved after 4 months of treatment.



Treatment of hair loss.

  • V. Price
  • Medicine
    The New England journal of medicine
  • 1999
This article will focus on the treatment of two common problems, androgenetic alopecia and alopECia areata, both of which involve a reversible alteration of the hair-growth cycle.

Disorders of hair growth : diagnosis and treatment

This book discusses the embryology and anatomy of the hair follicle, clinical tools for assessing hair growth, and the genetic and physical causes of hair loss, and scalp conditions of significance.

Classification scale for male and female androgenetic alopecia

Clinical Pharmacology & Therapeutics (1996) 59, 166–166; doi: 10.1038/sj.clpt.1996.164

Hemodynamic effects of minoxidil following intravenous infusions in untreated hypertensive patients

Clinical Pharmacology & Therapeutics (1996) 59, 166–166; doi: 10.1038/sj.clpt.1996.162