A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression.

@article{HerescoLevy2013ARA,
  title={A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression.},
  author={Uriel Heresco-Levy and Genia Gelfin and Boaz Bloch and Raz Levin and Shani Edelman and D. C. Javitt and Ilana Kremer},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 3},
  pages={501-6}
}
Antagonism of N-methyl-D-aspartate glutamatergic receptors (NMDAR) may represent an effective antidepressant mechanism. D-cycloserine (DCS) is a partial agonist at the NMDAR-associated glycine modulatory site that at high doses acts as a functional NMDAR antagonist. Twenty-six treatment-resistant major depressive disorder patients participated in a double blind, placebo-controlled, 6-wk parallel group trial with a gradually titrated high dose (1000 mg/d) of DCS added to their antidepressant… CONTINUE READING
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