A randomized, placebo-controlled trial of the effects of continuous combined hormone replacement therapy on coagulation and fibrinolytic systems in healthy postmenopausal women.

@article{Salobir2002ARP,
  title={A randomized, placebo-controlled trial of the effects of continuous combined hormone replacement therapy on coagulation and fibrinolytic systems in healthy postmenopausal women.},
  author={Barbara Gu{\vz}i{\vc} Salobir and Irena Keber and Lucija Vrabic},
  journal={Fertility and sterility},
  year={2002},
  volume={78 6},
  pages={1178-83}
}
OBJECTIVE To investigate the effects of combined hormone replacement therapy (HRT) on various parameters of coagulation and fibrinolysis that may contribute to increased risk for venous thromboembolic events. DESIGN Prospective, randomized, double-blind, placebo-controlled study. SETTING Academic hospital. PATIENT(S) Sixty-one healthy postmenopausal women with intact uterus. INTERVENTION(S) Patients were randomized to receive continuous combined HRT (estradiol, 2 mg/d, and… CONTINUE READING