A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis.

@article{Ruperto2007ARP,
  title={A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis.},
  author={Nicolino Ruperto and Daniel J. Lovell and Ruben Cuttica and N. A. Wilkinson and Pak-keung Woo and Graciela Espada and C. Wouters and Earl D Silverman and Zsolt Gy{\"o}rgy Balogh and Michael Henrickson and Maria-Teresa Apaz and Eileen Baildam and Anders L Fasth and Valeria Maria Gerloni and Pekka Lahdenne and Am. Prieur and Angelo Ravelli and Rotraud Katharina Saurenmann and Mar{\'i}a Luz G{\'a}mir G{\'a}mir and Nico M Wulffraat and L{\'a}szl{\'o} Mar{\'o}di and Ross Edward Petty and Renato Joos and Francesco Zulian and Debbie Mccurdy and Barry L. Myones and K{\'a}lm{\'a}n L{\'a}szl{\'o} Nagy and Peter D. Reuman and Ilona S. Szer and Suzanne Travers and Anna M Beutler and George A. Keenan and Jason B. Clark and Sudha Visvanathan and Adedigbo A. Fasanmade and Aparna Raychaudhuri and Alan M. Mendelsohn and Alberto Martini and Edward Harry Giannini},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 9},
  pages={
          3096-106
        }
}
OBJECTIVE To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA). METHODS This was an international, multicenter, randomized, placebo-controlled, double-blind study. One hundred twenty-two children with persistent polyarticular JRA despite prior methotrexate (MTX) therapy were randomized to receive infliximab or placebo for 14 weeks, after which all children received infliximab through week 44. Patients received MTX plus infliximab 3 mg/kg… CONTINUE READING
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