A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease.

@article{Hockenbery2007ARP,
  title={A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease.},
  author={David M. Hockenbery and Scott Cruickshank and Timothy C Rodell and Ted Gooley and Friedrich G. Schuening and Scott D. Rowley and Donald David and Mark W. Brunvand and Brian Berryman and Sunil H Abhyankar and Michelle Bouvier and George B McDonald},
  journal={Blood},
  year={2007},
  volume={109 10},
  pages={4557-63}
}
We tested the hypothesis that oral beclomethasone dipropionate (BDP) would control gastrointestinal graft-versus-host disease (GVHD) in patients with anorexia, vomiting, and diarrhea. Patients were randomized to prednisone for 10 days and either oral BDP 8 mg/d (n = 62) or placebo (n = 67) tablets for 50 days. At study day 10, prednisone was rapidly tapered while continuing study drug. On an intent-to-treat basis, the risk of GVHD-treatment failure was reduced for the BDP group at study day 50… CONTINUE READING

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