A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers

@inproceedings{Cassella2015ARP,
  title={A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers},
  author={James V. Cassella and Daniel A. Spyker and Paul P. Yeung},
  booktitle={International journal of clinical pharmacology and therapeutics},
  year={2015}
}
OBJECTIVE This randomized, double-blind, active- and placebo-controlled, crossover, thorough QT study assessed the effect of two inhaled loxapine doses on cardiac repolarization as measured by corrected QT (QTc) interval in healthy subjects (ClinicalTrials.gov NCT01854710). METHODS Subjects received two doses of inhaled loxapine (10 mg) 2 hours apart+oral placebo, two doses of inhaled placebo+oral placebo, or two doses of inhaled placebo+oral moxifloxacin (400 mg; positive control), with ≥3… CONTINUE READING