A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction.

@article{Wolstein2009ARO,
  title={A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction.},
  author={J{\"o}rg Wolstein and Markus T Gastpar and Thomas Finkbeiner and Cherrie A Heinrich and Ruth Heitkamp and Thomas Poehlke and N. Scherbaum},
  journal={Pharmacopsychiatry},
  year={2009},
  volume={42 1},
  pages={1-8}
}
INTRODUCTION Levo-Alpha-Acetylmethadol (LAAM) is a synthetic opioid analgesic with mu-agonistic activity and a long duration of action. There are several, almost exclusively US American studies showing the efficacy of LAAM as a maintenance drug which has the advantage that it needs to be administered only three times a week. LAAM is currently not marketed in EU countries due to cardiac complications. We report on the first European multi-center, parallel group, flexible dose, open-label… CONTINUE READING