A randomized, evaluator-blinded, two-center study of the safety and effect of volume on the diffusion and efficacy of botulinum toxin type A in the treatment of lateral orbital rhytides.

BACKGROUND There has been considerable discussion about the effect of the degree of dilution of botulinum toxin (BTX) but very few scientific studies. OBJECTIVE The objective was to observe as to whether a fivefold difference in concentration of BTX solution would produce a difference in clinical effect or duration of effect. METHODS AND MATERIALS… CONTINUE READING