A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines.

@article{Rimmelzwaan2000ARD,
  title={A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines.},
  author={Guus F Rimmelzwaan and Nella J. Nieuwkoop and Albrecht Brandenburg and Gerd Sutter and Walter E.P. Beyer and Darryl W. Maher and Jessica L. Bates and Albert D.M.E. Osterhaus},
  journal={Vaccine},
  year={2000},
  volume={19 9-10},
  pages={
          1180-7
        }
}
Although current influenza vaccines have been shown to reduce influenza-related morbidity and mortality, there is a desire to develop more efficacious products. Vaccines which can induce CD8(+) cytotoxic T cell (CTL) responses in addition to strong antibody responses may be more effective in preventing disease since it has been demonstrated that CTL contribute to protective immunity, even against drift variants of influenza A viruses. The immunogenicity of two types of experimental influenza… CONTINUE READING

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