A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis.

@article{Sands2008ARD,
  title={A randomized, double-blind, sham-controlled study of granulocyte/monocyte apheresis for active ulcerative colitis.},
  author={Bruce E Sands and W J Sandborn and Brian G Feagan and Robert L{\"o}fberg and Toshifumi Hibi and Tao Wang and Lisa-Marie Gustofson and Cindy J. Wong and Margaret K. Vandervoort and Stephen Hanauer},
  journal={Gastroenterology},
  year={2008},
  volume={135 2},
  pages={400-9}
}
BACKGROUND & AIMS Activated granulocytes and monocytes/macrophages are implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical experience in Japan and Europe have suggested that granulocyte/monocyte apheresis is safe and effective in treating ulcerative colitis. METHODS We evaluated the efficacy of granulocyte/monocyte apheresis in a randomized, double-blind, sham-controlled trial in patients with active moderate-to-severe ulcerative colitis (Mayo score 6-11) in… CONTINUE READING
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Intensive granulocyte and monocyte apheresis versus intravenous prednisolone in patients with severe ulcerative colitis : a multicenter randomized controlled trial ( abstr )

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