A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis.

@article{Chonchol2009ARD,
  title={A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis.},
  author={Michel B. Chonchol and Francesco Locatelli and Hanna Emily Abboud and Chaim Charytan and Angel L. M. de Francisco and Shivinder S Jolly and Mark Kaplan and Simon D. Roger and Shyamal Sarkar and Moetaz B Albizem and T Christian H Mix and Yumi Kubo and Geoffrey A. Block},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2009},
  volume={53 2},
  pages={197-207}
}
BACKGROUND Secondary hyperparathyroidism is observed in patients with early chronic kidney disease (CKD). This study investigated the safety and efficacy of cinacalcet for secondary hyperparathyroidism in participants with CKD not receiving dialysis. STUDY DESIGN Double-blind, randomized, 32-week, phase 3 study. SETTING & PARTICIPANTS 404 participants with stage 3 or 4 CKD from 73 centers in 9 countries. INTERVENTIONS Cinacalcet:placebo (3:1 ratio). OUTCOMES & MEASUREMENTS Proportion of… CONTINUE READING
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Impact f ergocalciferol treatment of vitamin D deficiency on serum arathyroid hormone concentrations in chronic kidney dis

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