A randomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor.

@article{Jankovic1996ARD,
  title={A randomized, double-blind, placebo-controlled study to evaluate botulinum toxin type A in essential hand tremor.},
  author={Joseph Jankovic and Kristoffer Schwartz and W Clemence and A S Aswad and Julie Mordaunt},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1996},
  volume={11 3},
  pages={250-6}
}
Twenty-five patients with hand tremor of 2+ (moderate) to 4+ (severe) on the tremor severity rating scale were randomized to receive either 50 U of botulinum toxin (BTX) type A (Allergan, Irvine, CA) or placebo injections into the wrist flexors and extensors of the dominant limb. If patients failed to respond to the initial injection, they were eligible to receive another injection of 100 U 4 weeks later. Rest, postural, and kinetic tremors were evaluated at 2- to 4-week intervals over a 16… CONTINUE READING

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