A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome

@article{Rao2009ARD,
  title={A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome},
  author={A. Venket Rao and Alison C. Bested and Tracey M Beaulne and Martin A Katzman and Christina R. Di Iorio and John M Berardi and Alan C Logan},
  journal={Gut Pathogens},
  year={2009},
  volume={1},
  pages={6 - 6}
}
Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Research shows that patients with CFS and other so-called functional somatic disorders have alterations in the intestinal microbial flora. Emerging studies have suggested that pathogenic and non-pathogenic gut bacteria might influence mood-related symptoms and even behavior in animals and humans… 
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References

SHOWING 1-10 OF 33 REFERENCES
Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation.
TLDR
The results indicate a beneficial effect on gastrointestinal symptoms of patients with Chronic constipation and the administration of probiotic foodstuffs may be recommended as an adjunctive therapy of chronic constipation.
Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value.
Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome.
TLDR
Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO, and the loss of ERBHAL was associated with reduced symptoms.
Impact of consuming a milk drink containing a probiotic on mood and cognition
TLDR
The consumption of a probiotic-containing yoghurt improved the mood of those whose mood was initially poor, and this improvement in mood was not, however, associated with an increased frequency of defaecation.
Major depressive disorder: probiotics may be an adjuvant therapy.
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.
TLDR
The results show that normalization of the IgA and IgM responses to translocated LPS may predict clinical outcome in CFS, and support the view that a weakened tight junction barrier with subsequent gut-derived inflammation is a novel pathway inCFS and that it is a new target for drug development in C FS.
Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder.
TLDR
Preliminary evidence is provided that patients with CFS, FM, and TMD share key symptoms, and it also is apparent that other localized and systemic conditions may frequently co-occur with C FS,FM, andTMD.
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?
TLDR
Multivariate statistical analyses suggest that gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders are distinct disorders and not manifestations of a common somatization disorder, but their strong comorbidity suggests a common feature important to their expression, which is most likely psychological.
An examination of the working case definition of chronic fatigue syndrome.
...
...