A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease.

  title={A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease.},
  author={K. Kieburtz and G. Landwehrmeyer and M. Cudkowicz and E. Dorsey and A. Feigin and V. Hunt and E. Kayson and M. Mcdermott and S. Noonberg and W. Seitz and P. Soliveri and F. Walker and Burgunder J-M. and I. Romero and A. Magara and Y. Stebler and H. Rickards and J. Wright and J. D. Souza and R. Barker and S. Mason and A. D. Pietro and A. Goodman and D. O'Keeffe and M. Langlois and G. Ferland and L. Verret and S. Chouinard and S. Paris and C. Lepage and A. Nemeth and C. Merritt and C. Cox and T. Astbury and S. Murphy and Anwar Ahmed and P. S. Marie and R. A. Berila and C. Kubu and V. Segro and R. Kumar and D. Erickson and J. Schneiders and S. Frucht and Paula Wasserman and C. Moskowitz and B. Scott and P. Perry-Trice and S. Wyne and D. Parida and V. Redaelli and W. Sołtan and P. Robowski and M. Nowak and M. Schinwelski and A. Dziadkiewicz and T. Andrews and D. Ruddy and A. Dougherty and K. Boelmans and J. Schmalfeld and A. Muenchau and S. Zittel and W. Mallonee and G. Suter and J. Tan and L. Seeberger and Jenny Harris and J. Champion and J. Wojcieszek and J. Belden and Kathy Price and M. Hughes-Gay and G. Sprehn and F. Squitieri and T. Martino and F. Gregorio and A. D. Nicola and F. Elifani and A. Rosenblatt and N. Yoritomo and R. Margolis and P. Nichols and S. P{\aa}lhagen and A. Hoglund and M. Paucar and T. W. Reza-Soltani and A. Beister and T. Raab and J. Kieni and C. Schrenk and K. Banaszkiewicz and J. Misztela and M. W{\'o}jcik and E. Szczygieł and M. Golosz and M. Rudzinska and Roos Rac. and van den Bogaard Sja. and R. Bos and S. J. Booij and C. Hyson and J. Megens and E. Makaji and M. Jenkins and S. Hersch and S. Maya and C. Dresser and D. Rosas and K. Blindauer and C. Schindler and S. Hung and A. McNees and S. Tabrizi and M. Novak and M. Say and Anil D. Patel and P. Panegyres and N. Lewis and S. Jukich and C. Faull and L. Hjermind and O. Jakobsen and A. Vogel and T. Nielsen and J. Nielsen and S. Kostyk and A. Seward and P. Agrawal and J. Kraakevik and P. Hogarth and A. Wilson and J. Lear and P. Kraus and C. Saft and T. Steiner and R. Hoffmann and C. Stamm and J. Schollhammer and I. Uhl and B. Kaminski and K. O'Donovan and O. Quarrell and L. Nevitt and C. Kipps and A. Hare and K. Gunner and E. Hayward and M. Nance and J. Hamerlinck and C. Wielinski and O. Yastrubetskaya and E. Chiu and P. Chua and B. Mannaa and M. Tommaso and C. Serpino and C. Cormio and V. Sciruicchio and G. Michele and L. Maio and C. Russo and F. Sacc{\`a} and E. Salvatore and T. Tucci and M. Wolz and L. Klingelhoefer and A. Wolz and S. Schmidt and A. Storch and E. Spruth and S. Thiel and B. Neumann and H. Gelderblom and J. Priller and C. Sass and D. Probst and C. Werner and B. Leavitt and A. Coleman and L. Raymond and V. Wheelock and T. Tempkin and K. Baynes and N. Hermanowicz and Shari Niswonger and M. Haske-palomino and Y. Bordelon and A. Gratiano and A. Johnson and J. Corey-Bloom and J. Goldstein and G. Peavy and M. Geschwind and J. Gooblar and C. Barton and H. Fernandez and Ramon Rodriguez and M. Suelter and M. Daniels and J. Romrell and C. Swartz and L. Beglinger and E. Epping and E. Waterman and Megan M. Smith and R. Dubinsky and H. Dubinsky and C. Gray and D. Craufurd and E. Howard and M. Jones and H. Murphy and K. Anderson and C. Nickerson and J. Santo and T. Rigaud and N. Zappala and B. Robottom and C. Singer and M. Quesada and K. Rodriguez-Spengler and R. H. Cardenach{\'e} and R. Reilmann and S. Bohlen and H. E-M. and A. Colcher and H. Maccarone and L. Altin and A. Siderowf and T. Greenamyre and N. Lucarelli and L. Ivan{\vc}o and F. Marshall and C. Hickey and L. Deuel and K. Biglan and S. S{\"u}ssmuth and M. Orth and S. Trautmann and C. Eschenbach and A. Samii and Alma Macaraeg and D. Zielonka and A. Ciesielska and J. Marcinkowski and J. Sempołowicz and H. Karaskiewicz and C. O'Neill and I. Haq and G. Witkowski and J. Antczak and R. Rola and P. Richter and M. Rakowicz and K. Jachińska and S. Criswell and P. Deppen and K. Wharton and N. Mahant and E. McCusker and J. Griffith and C. Loy and L. Stewart and D. Fisher and D. Holt and C. Orme and A. Watts and J. Weber and K. White and R. Hauser and R. Albin and C. Coffey and W. Fischer and J. Miyasaki and Investigators Horizon.},
  journal={JAMA neurology},
  volume={70 1},
BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease. OBJECTIVE To determine the effect of latrepirdine on cognition and global function in patients with mild to moderate Huntington disease. DESIGN Randomized, double-blind, placebo-controlled study. SETTING Sixty-four research centers in Australia… Expand
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