A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina.

@article{Grines2003ARD,
  title={A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina.},
  author={Cindy Lee Grines and Matthew W. Watkins and John J. Mahmarian and Ami E. Iskandrian and Jeffrey J. Rade and Pran Marrott and Craig M. Pratt and Neal S. Kleiman},
  journal={Journal of the American College of Cardiology},
  year={2003},
  volume={42 8},
  pages={1339-47}
}
OBJECTIVES The primary objective of this study was to determine whether intracoronary administration of the adenoviral gene for fibroblast growth factor (Ad5FGF-4) can improve myocardial perfusion compared with placebo. BACKGROUND Animal studies and observational clinical studies have shown improvement in perfusion of the ischemic myocardium using genes encoding angiogenic growth factors; however, randomized, double-blind data in humans are lacking. METHODS We performed a randomized, double… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
A randomized , double - blind , placebo - controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina .
A randomized , double - blind , placebo - controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina .
A randomized , double - blind , placebo - controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina .
A randomized , double - blind , placebo - controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina .
All Topics