A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder.

@article{Cusin2013ARD,
  title={A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder.},
  author={Cristina Cusin and Nadia Iovieno and Dan V. Iosifescu and Andrew A. Nierenberg and Maurizio Fava and Augustus John Rush and Roy H. Perlis},
  journal={The Journal of clinical psychiatry},
  year={2013},
  volume={74 7},
  pages={
          e636-41
        }
}
BACKGROUND Multiple treatments for patients with major depressive disorder (MDD) have demonstrated efficacy, but up to one-third of individuals with MDD do not achieve symptomatic remission despite various interventions. Existing augmentation or combination strategies can have substantial safety concerns that may limit their application. METHOD This study investigated the antidepressant efficacy of a flexible dose of the dopamine agonist pramipexole as an adjunct to standard antidepressant… CONTINUE READING
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