A randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy, safety, and tolerability of extended-release metadoxine in adults with attention-deficit/hyperactivity disorder.

@article{Manor2012ARD,
  title={A randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy, safety, and tolerability of extended-release metadoxine in adults with attention-deficit/hyperactivity disorder.},
  author={Iris Manor and Rachel Ben-Hayun and Judith Aharon-peretz and Dana Salomy and Avraham Weizman and Yaron Daniely and Dalia Megiddo and Jeffrey H. Newcorn and Joseph Biederman and Lenard A Adler},
  journal={The Journal of clinical psychiatry},
  year={2012},
  volume={73 12},
  pages={
          1517-23
        }
}
OBJECTIVE To evaluate the efficacy, safety, and tolerability of an oral extended-release (ER) formulation of the nonstimulant metadoxine in the treatment of adult attention-deficit/hyperactivity disorder (ADHD). METHOD This was a 1:1 randomized, double-blind, placebo-controlled, parallel-design, phase 2 study of metadoxine ER 1,400 mg/d treatment for 6 weeks, following a 2-week baseline/screening period, involving 120 adults with DSM-IV-defined ADHD. A follow-up assessment occurred 2 weeks… CONTINUE READING
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