A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia.

@article{Keefe2001ARD,
  title={A randomized, double blind, Phase III trial using oral beta-carotene supplementation for women with high-grade cervical intraepithelial neoplasia.},
  author={Kristin A. Keefe and Michael J. Schell and Carole Brewer and Michael McHale and Wendy Brewster and Julie A Chapman and Garrett S. Rose and D. Scott McMeeken and Westley Lagerberg and Yei Mei Peng and Sharon P. Wilczynski and Hoda Anton-Culver and Frank L. Meyskens and Michael L. Berman},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2001},
  volume={10 10},
  pages={1029-35}
}
To evaluate the effect of daily beta-carotene (30 mg) versus placebo over a 2-year period on cervical intraepithelial neoplasia (CIN) 2 and 3 lesions. Human papillomavirus (HPV) typing was done to determine whether lesion regression was related to HPV. Micronutrient levels were measured to determine whether levels were predictive of regression. Variables that influence the risk of HPV infection and CIN, such as cigarette smoking and sexual behavior, were evaluated. Women were randomized to beta… CONTINUE READING

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