A randomized, controlled trial to assess the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers.

@article{Glover2007ARC,
  title={A randomized, controlled trial to assess the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers.},
  author={Elbert D. Glover and Molly T Laflin and Kory J. Schuh and Leslie M. Schuh and Mitch Nides and Arden G. Christen and Penny N. Glover and Julia V Strnad},
  journal={Addiction},
  year={2007},
  volume={102 5},
  pages={795-802}
}
AIMS To determine the efficacy and safety of nicotine transdermal therapy co-administered with the nicotine antagonist, mecamylamine, compared to a nicotine transdermal patch alone (21 mg nicotine + 6 mg mecamylamine, 21 mg nicotine + 3 mg mecamylamine, and 21 mg nicotine + 0 mg mecamylamine). DESIGN Multi-center (n = 4), double-blind, randomized, parallel group, repeat-dose study. SETTING Clinical laboratory. PARTICIPANTS A total of 540 subjects were enrolled into the study-135 from each… CONTINUE READING

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