A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia.

@article{Shiffman1999ARC,
  title={A randomized, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia.},
  author={Mitchell L. Shiffman and Charlotte M Hofmann and Melissa J Contos and Velimir A.C. Luketic and Arun J Sanyal and Richard Keith Sterling and Andrea Ferreira-Gonzalez and Alan Scott Mills and C{\'e}line Garret},
  journal={Gastroenterology},
  year={1999},
  volume={117 5},
  pages={1164-72}
}
BACKGROUND & AIMS : At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histological progression in this subset of nonresponders. METHODS Fifty-three patients with chronic HCV were enrolled. All were HCV-RNA positive after 6 months of treatment with… CONTINUE READING

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