A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain.

@article{Ernst1997ARC,
  title={A randomized, controlled trial of intravenous clodronate in patients with metastatic bone disease and pain.},
  author={D. Scott Ernst and Penny Brasher and Neil Hagen and Alexander HG Paterson and Robert N. MacDonald and Eduardo Bruera},
  journal={Journal of pain and symptom management},
  year={1997},
  volume={13 6},
  pages={319-26}
}
To evaluate the effectiveness of intravenous clodronate in ameliorating refractory bone pain in patients with metastatic bone disease, 60 patients with established osseous metastases and persistent bone pain were randomized to receive either clodronate (600 mg or 1500 mg in 500 mL of normal saline) or 500 mL of saline as placebo. After 2 weeks, the patients were crossed over to receive the alternate treatment. After another 2 weeks, each patient and investigator made a blinded choice. Daily… CONTINUE READING

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