A randomized, controlled trial of gabapentin enacarbil in subjects with neuropathic pain associated with diabetic peripheral neuropathy.

@article{Rauck2013ARC,
  title={A randomized, controlled trial of gabapentin enacarbil in subjects with neuropathic pain associated with diabetic peripheral neuropathy.},
  author={Richard L. Rauck and Clare W. Makumi and Sherwyn Schwartz and Ole X Graff and Guy M. L. Meno-Tetang and Christopher F Bell and Sarah T. Kavanagh and Carrie L McClung},
  journal={Pain practice : the official journal of World Institute of Pain},
  year={2013},
  volume={13 6},
  pages={
          485-96
        }
}
BACKGROUND Gabapentin enacarbil (GEn), a transported prodrug of gabapentin, provides sustained, dose-proportional gabapentin exposure. The purpose of this study was to investigate the dose response of GEn to select the optimal dose(s) for clinical use in subsequent diabetic peripheral neuropathy (DPN) trials. METHODS This was a multicenter, randomized, double-blind, double-dummy, parallel group, placebo-controlled trial with a study duration of approximately 20 weeks (Clinicaltrials.gov… CONTINUE READING
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