A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus.

@article{Roberts2011ARC,
  title={A randomized, controlled study comparing the effects of vestipitant or vestipitant and paroxetine combination in subjects with tinnitus.},
  author={Claire Roberts and Amir Inamdar and Annelize Koch and Pauline Kitchiner and Odile Dewit and Emilio Merlo-Pich and Paolo Fina and Don McFerran and David M Baguley},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  year={2011},
  volume={32 5},
  pages={
          721-7
        }
}
OBJECTIVE Tinnitus is a common symptom that demonstrates a significant comorbidity with anxiety and depression. The novel neurokinin-1 receptor antagonist, vestipitant, has anxiolytic properties and a good safety profile. Vestipitant was investigated for potential effect against chronic tinnitus as a stand-alone treatment and in conjunction with a selective serotonin reuptake inhibitor, paroxetine. STUDY DESIGN Randomized, double-blind, crossover study. SETTING Tertiary neurotologic and… CONTINUE READING
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