A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopy.

@article{Mandel2008ARC,
  title={A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopy.},
  author={J. Elizabeth Mandel and Jonathan W. Tanner and Gary R Lichtenstein and David C. Metz and David A Katzka and Gregory G. Ginsberg and Michael L. Kochman},
  journal={Anesthesia and analgesia},
  year={2008},
  volume={106 2},
  pages={
          434-9, table of contents
        }
}
BACKGROUND Patient-controlled sedation (PCS) with propofol has been advocated as a method for dealing with the narrow therapeutic window for moderate sedation, but previous studies have methodologic limitations. We hypothesized that, by using remifentanil in conjunction with propofol and using PCS in both arms of the study, we could demonstrate marked improvements in facility use compared with fentanyl plus midazolam. METHODS Fifty patients undergoing elective colonoscopy were randomized… CONTINUE READING

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