A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL).

@article{Ladas2010ARC,
  title={A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL).},
  author={Elena J. Ladas and David J. Kroll and Nicholas H Oberlies and Bin Cheng and Deborah Hughes Ndao and Susan R. Rheingold and Kara M Kelly},
  journal={Cancer},
  year={2010},
  volume={116 2},
  pages={506-13}
}
BACKGROUND Despite limited preclinical and clinical investigations, milk thistle (MT) is often used for the treatment of chemotherapy-associated hepatotoxicity. Limited treatment options exist for chemotherapy-related hepatoxicity. Given the wide use of MT, the authors investigated MT in both the laboratory and a clinical setting. METHODS In a double-blind study, children with acute lymphoblastic leukemia (ALL) and hepatic toxicity were randomized to MT or placebo orally for 28 days. Liver… CONTINUE READING
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