A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study.

@article{Frieling2000AR1,
  title={A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study.},
  author={Uta M Frieling and Debra A. Schaumberg and Thomas S Kupper and J{\"o}rg Muntwyler and Charles H. Hennekens},
  journal={Archives of dermatology},
  year={2000},
  volume={136 2},
  pages={179-84}
}
CONTEXT Although basic research provides plausible mechanisms for benefits of beta carotene supplementation on nonmelanoma skin cancer (NMSC) primarily consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), observational studies are inconsistent. Randomized trial data are limited to 1 trial of secondary prevention that showed no effect of beta carotene on the incidence of NMSC after 5 years. OBJECTIVE To test whether supplementation with beta carotene reduces the risk for… CONTINUE READING