A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota.

@article{Watson2018ART,
  title={A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota.},
  author={Henry Watson and Suparna Mitra and Fiona C Croden and Morag Taylor and Henry M. Wood and Sarah L Perry and Jade A Spencer and Philip Quirke and Giles John Toogood and Clare L Lawton and Louise Dye and Paul M. Loadman and Mark A Hull},
  journal={Gut},
  year={2018},
  volume={67 11},
  pages={
          1974-1983
        }
}
OBJECTIVE Omega-3 polyunsaturated fatty acids (PUFAs) have anticolorectal cancer (CRC) activity. The intestinal microbiota has been implicated in colorectal carcinogenesis. Dietary omega-3 PUFAs alter the mouse intestinal microbiome compatible with antineoplastic activity. Therefore, we investigated the effect of omega-3 PUFA supplements on the faecal microbiome in middle-aged, healthy volunteers (n=22). DESIGN A randomised, open-label, cross-over trial of 8 weeks' treatment with 4 g mixed… CONTINUE READING

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