A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung.

@article{Guerrieri2004ARP,
  title={A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung.},
  author={M. Sottili Guerrieri and Kevin Wong and Gail Ryan and Michael Millward and George Quong and David Ball},
  journal={Lung cancer},
  year={2004},
  volume={46 1},
  pages={107-11}
}
PURPOSE To determine if the addition of carboplatin chemotherapy to whole brain irradiation improves response and survival in patients with brain metastases from non-small cell lung cancer (NSCLC). PATIENTS AND METHODS Forty-two patients with brain metastases from NSCLC and performance status ECOG 0-2 were randomised to receive either whole brain radiotherapy (WBRT) alone (20Gy in five fractions) or the same radiotherapy plus concomitant carboplatin (70 mg/m(2) intravenously for 5 days… CONTINUE READING